A placebo controlled trial of medical treatment of submucous fibroids with Gonadotrophin Releasing Hormone (GnRH) analogues prior to hysteroscopic resection

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN75436772

Enrollment

120

Registered

2005-11-30

Start date

2005-10-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Submucous fibroids Urological and Genital Diseases Other noninflammatory disorders of uterus, except cervix

Interventions

This randomised double blind placebo controlled trial will include women referred for ultrasound assessment because of a history of excessive menstrual bleeding. Those found on ultrasound examination

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. Women with symptomatic submucous fibroids diagnosed on saline infusion hydrosonography 2. Fibroids suitable for hysteroscopic resection 3. Written informed consent obtained

Exclusion criteria

Exclusion criteria: 1. Fibroids not suitable for hysteroscopic resection 2. Written informed consent declined 3. Malignant histology discovered on histological analysis

Design outcomes

Primary

Measure	Time frame
The success of hysteroscopic resection in achieving complete removal of fibroid.	—

Secondary

Measure	Time frame
The length of the operation and associated complications in both treatment and placebo group.	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026