Analysis of the Pseudomonas aeruginosa biofilm in the respiratory samples of cystic fibrosis patients

Effect of intrapulmonary percussive ventilation on Pseudomonas aeruginosa biofilm formation and virulence

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN75391385

Enrollment

Registered

2013-02-06

Start date

2012-01-01

Completion date

Unknown

Last updated

2018-04-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cystic fibrosis / Pseudomonas aeruginosa biofilm / Intrapulmonary Percussive Ventilation (IPV) Nutritional, Metabolic, Endocrine Cystic fibrosis, unspecified

Interventions

Three different physiotherapy regimens (each patient will have all 3 regimens with a 3-month interval): 1. Autogenous drainage 2. IPV low frequency (200 bpm) 3. IPV high frequency (400 bpm)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. CF patients (diagnosis confirmed by sweat test) 2. Age greater than 6 years, upper age limit 60 years 3. Hospitalisation 3 to 4 times a year for routine intravenous (IV) antibiotic treatment 4. Clinically stable at time of study entry

Exclusion criteria

Exclusion criteria: 1. Lung transplantation 2. Massive hemoptysis 3. Pneumothorax 4. Pregnancy 5. Non-invasive and invasive ventilation

Design outcomes

Primary

Measure	Time frame
Analysis of P. aeruginosa abundance, physiology, virulence factors and gene expression on day 1, day 4 and day 10 of each hospitalisation	—

Secondary

Measure	Time frame
Lung function values [Forced expiratory volume in the first one second (FEV1) and forced vital capacity (FVC)] on day 1 and day 10 of each hospitalisation	—

Countries

Belgium

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 7, 2026