Acute coronary syndrome Circulatory System Acute coronary syndrome
Conditions
Interventions
Sustained-release bupropion versus placebo.
Sponsors
Sir Mortimer B Davis Jewish General Hospital (Canada)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age: greater than or equal to 18 years 2. Active smoker (greater than or equal to 10 cigarettes per day, on average) for the past year 3. Suffered an ACS and planned hospitalization of greater than or equal to 48 hours ACS is defined as positive Troponin T, Troponin I, or CK-MB levels and greater than or equal to one of the following: 3.1. Ischaemic symptoms (i.e. typical chest pain) for at least 20 minutes 3.2. Electrocardiogram (ECG) changes indicative of ischemia (ST-segment elevation or depression) 3.3. Development of pathological Q waves on the ECG Note: If patient is to undergo percutaneous coronary intervention (PCI) and/or coronary artery bypass graft surgery (CABG), they are still eligible to be enrolled. 4. Motivated to quit smoking
Exclusion criteria
Exclusion criteria: 1. Current seizure disorder, history of seizures, or predisposition to seizures (e.g. history of brain tumour, severe head trauma, or stroke) 2. Current use of medications that lower seizure threshold e.g. amantadine, anti-depressants, anti-malarials, anti-psychotics, levodopa, lithium, quinalone antibiotics, ritonavir, systemic steroids, theophyllin, type 1C antiarrhythmics (e.g. encainide, flecainide, propafenone) 3. History of anorexia nervosa or bulimia 4. Current use of Wellbutrin or any other medications that contain bupropion 5. Pregnancy or lactation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Smoking abstinence rates at 12 months post-ACS | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Cumulative side effects and safety of bupropion at 9 weeks 2. Composite clinical events (unstable angina, myocardial infarction [MI], seizure, death) | — |
Countries
Canada
Outcome results
None listed