Malaria Infections and Infestations Malaria
Conditions
Interventions
A randomised comparison of three oral antimalarial combinations.
1. Chloroquine plus sulfadoxine-pyrimethamine
2. Artesunate plus mefloquine
3. Artemether-lumefantrine
42-day follow-up period.
Sponsors
University of Oxford (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients or their guardians gave fully informed written consent 2. Had a density of asexual P. falciparum of 5000 to 200,000 per microlitre of blood 3. Were aged more than one year 4. Had an axillary temperature of more than 37.5°C or history of fever in the previous three days 5. Were likely to stay in the hospital until parasite clearance and complete the 42-day follow up period
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating women 2. Patients who took a full course of any antimalarials in the previous three days 3. Patients with signs of severe malaria 4. Those with history of allergy or contraindication to the study drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Parasitological and clinical responses to treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Parasite and fever clearance times 2. Gametocytaemia 3. Changes in haematocrit following antimalarial treatment | — |
Countries
Laos
Outcome results
None listed