Dengue, severe dengue Infections and Infestations Dengue fever [classical dengue]
Conditions
Interventions
The trial will compare existing (nos 1 & 2) and ?novel? (3 and 4) approaches for targeting dengue vectors in a high-density urban community:
1. Outdoor fogging (OF) ? using standard protocols. Space
delivered by teams of operators using dedicated equipment. Used outdoors, it is timed to coincide with flying times of the vectors (ideally soon after sunrise).
2. Indoor Space-Spraying (ISS) - u
here a liquid spray of insecticide is applied directly to the walls inside the home by teams of operators using dedicated equipment
a frontline highly effective method for malaria control for over 50 years, it has never been evaluated for its potential against Aedes aegypti as a dengue prevention method. A single treatment can re
Syngenta), in one of three formulations:-
5.1. Icon EC (emulsifiable concentrate) for outdoor fogging and indoor space spraying
diluted in kerosene or dies
Sponsors
Liverpool School of Tropical Medicine (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: All occupied households
Exclusion criteria
Exclusion criteria: 1. Business-only premises 2. Unoccupied premises
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficacy of the intervention will be determined by measuring a range of entomological indices. Acceptance and other perceptions of the interventions will be evaluated using brief questionnaire surveys at baseline and final follow-up. 1. Measure the impact of each treatment on the adult and larval mosquito population densities in the clusters. Dengue vector populations will be measured using the Adult index (AI - proportion of houses positive for adult Ae. aegypti) and standard Stegomyia indices: 1.1. Breteau index (BI - number of containers with immature vector stages/100 houses), House index (HI - percentage of houses found with immature stages of Ae. aegypti) and container index (CI - percentage of water-holding containers found with immature stages of Ae. aegypti). We will also measure the Pupal index (PI - number of pupae per number of people), a proxy for adult populations, and deploy ovitraps as sensitive indicators of Aedes spp. presence or absence. | — |
Secondary
| Measure | Time frame |
|---|---|
| Interview surveys used to determine: 1. Household characteristics 2. Precious and current vector control intervention 3. Understanding of the local population's knowledge, attitudes and practice about dengue prevention and control, and the interventions being tested 4. Insecticide-susceptibility assays undertaken before, at follow-up surveys and after intervention Each house will be geo referenced with a handheld global positioning system receiver to permit potential effects between clusters to be quantified. | — |
Countries
Indonesia
Outcome results
None listed