Calf thrombosis/below knee DVT Circulatory System Other venous embolism and thrombosis
Conditions
Interventions
Patients will be randomised to one of the following treatment groups
1. Group A: conservative treatment (TED stockings and simple analgaesia) and full-dose anticoagulation, initiated with Low Molecula
Sponsors
Central Manchester NHS Foundation Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. All ambulatory outpatients presenting to Manchester Royal Infirmary Emergency department diagnosed with below knee calf vein thrombosis by vascular ultrasound scan (USS) 2. Able to give informed consent 3. Aged 16-90
Exclusion criteria
Exclusion criteria: 1. Hospitalised patients 2. Patients on long-term anticoagulation 3. Associated proximal DVT or confirmed PE 4. Contraindication to anticoagulation (active bleeding, recent haemorrhagic CVA or upper GI bleed) 5. Other indication for immediate warfarinisation as per BSH guidelines: Prior confirmed and treated above knee DVT/PE, antiphospholipid syndrome, symptomatic inherited thrombophilia 6. Pregnancy 7. Chronic non propagating thrombus seen on prior USS 8. Previous enrolment to the ACT study and achievement of the primary outcome
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Combined incidence of thrombus propagation above knee or development of pulmonary embolism during the 3 months randomisation period | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Incidence of major and minor bleeding episodes 2. Incidence of post thrombotic leg syndrome at 2 years using validated screening tool 3. Incidence of DVT recurrence at 2 years | — |
Countries
United Kingdom
Outcome results
None listed