Hyponatraemia Nutritional, Metabolic, Endocrine Hyponatraemia
Conditions
Interventions
The patients were randomized to one of the three study arms prospectively. Stratified block randomization was performed, with each one-week block featuring a different intravenous solution. Randomizat
Sponsors
Istanbul University, Faculty of Medicine (Turkey)
Eligibility
Inclusion criteria
Inclusion criteria: All children aged between 3 months to 16 years old who received intravenous fluids
Exclusion criteria
Exclusion criteria: 1. Dehydration 2. Cerebral oedema 3. Nephrotic syndrome 4. Hepatorenal syndrome 5. Plasma sodium level below 135 mmol/L 6. Congestive heart failure 7. Renal failure 8. Inborn error of metabolism 9. Protein energy malnutrition 10. Patients receiving mannitol or diuretics 11. Patients whose fluid therapy was started before admission
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Association between administration of hypotonic fluids and hospital-acquired hyponatraemia, assessed by the following: 1. Plasma sodium, potassium and osmolality in all blood samples collected at admission (T0) and 12 (T12), 24 (T24), 48 (T48) and 72 (T72) hours of intravenous fluids therapy 2. Plasma urea, creatinine and uric acid, measured in all blood samples collected at T0 and T24 | — |
Secondary
| Measure | Time frame |
|---|---|
| To determine contributive factors that may increase hyponatraemia risk, assessed by the following: 1. Plasma sodium, potassium and osmolality in all blood samples collected at admission (T0) and 12 (T12), 24 (T24), 48 (T48) and 72 (T72) hours of intravenous fluids therapy. 2. Plasma urea, creatinine and uric acid, measured in all blood samples collected at T0 and T24. 3. Plasma AntiDiuretic Hormone (ADH), measured at T0. Abnormal ADH function was assessed by serum osmolality and serum sodium determinations. | — |
Countries
Turkey
Outcome results
None listed