Periodontitis (gum disease) in people living with mild dementia Oral Health Chronic periodontitis
Conditions
Interventions
Carried out by dentists:
1. Standard dental health protocols for periodontitis
2. Periodontal monitoring
Carried out by clinical psychologist:
3. Cognitive assessment and assessment of daily living
Sponsors
University of Bristol (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Current participant inclusion criteria as of 29/05/2019: 1. Adults with mild dementia, such as sporadic early-stage AD, mild early stage familial AD, mixed dementia (most commonly AD and vascular dementia) and vascular dementia associated with cerebral amyloid angiopathy, mild cognitive impairment (MCI) 2. Cognitive scores that demonstrate the patient is likely to have the capacity to consent 3. Moderate to severe periodontitis 4. =2 sextants score 4 on Basic Periodontal Examination (BPE) 5. Minimum of 6 remaining teeth 6. A project partner (commonly a carer or friend) who will consent to take part in the study in this capacity and attend appointments with the participant Previous participant inclusion criteria: 1. Adults with mild dementia, such as sporadic early-stage AD, mild early stage familial AD, mixed dementia (most commonly AD and vascular dementia) and vascular dementia associated with cerebral amyloid angiopathy 2. Cognitive scores that demonstrate the patient is likely to have the capacity to consent 3. Moderate to severe periodontitis 4. =2 sextants score 4 on Basic Periodontal Examination (BPE) 5. Minimum of 6 remaining teeth 6. A project partner (commonly a carer or friend) who will consent to take part in the study in this capacity and attend appointments with the participant
Exclusion criteria
Exclusion criteria: 1. Insufficient capacity to consent 2. Previously fitted pacemaker 3. Allergy to essential oil mouthwash 4. Tobacco smoking 5. Uncontrolled systemic disease 6. Uncontrolled dental disease other than periodontitis 7. Pregnancy or breastfeeding 8. Severe renal impairment (GFR=30ml/min) 9. Those scoring =3 on the American Society of Anaesthesiologists (ASA) Physical Status Classification System 10. Those currently enrolled in another study whose inclusion/exclusion criteria state that while on the study they cannot enrol in new studies, such as the Oral Health Study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measured on day 0, 6 months, 1 year and 2 years. Additional appointments will be required for periodontal stabilisation during the 2 years (exact timepoints cannot be specified). 1. Compliance: 1.1. Attendance of visits 1.2. Short questionnaire about ease of following the oral hygiene regime 2. Stabilisation of periodontitis: periodontal assessment to include: 2.1. Tooth mobility 2.2. Bone loss 2.3. Bleeding on probing 2.4. Presence of pus 2.5. Periodontal pocket depth 2.6. Plaque assessment as determined by Turesky plaque index 2.7. Saliva sample for bacterial load determination | — |
Secondary
| Measure | Time frame |
|---|---|
| Measured on day 0, 6 months, 1 year and 2 years. Additional appointments will be required for periodontal stabilisation during the 2 years (exact timepoints cannot be specified). Cognitive improvement: 1. Addenbrooke’s Cognitive Examination III 2. Alzheimer’s disease quality of life assessment (DEMQOL) 3. Bristol Activities of Daily Living (BADLS) | — |
Countries
England, United Kingdom
Contacts
Public ContactNicola Hellin
Outcome results
None listed