Measuring levels of maternal cell microRNAs to predict adverse pregnancy outcome

Measuring levels of maternal cell microRNAs to predict adverse pregnancy outcome: a longitudinal observational study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN74967568

Enrollment

209

Registered

2018-01-09

Start date

2018-01-30

Completion date

Unknown

Last updated

2021-07-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Couples that have successfully conceived Pregnancy and Childbirth

Interventions

Peripheral blood is drawn from a pregnant patient at 8-10 weeks, the sample undergoes separation/extraction of PBMCs which is stored at -80°C. miRNA isolation, miRNA quantification, reverse transcript

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Successfully pregnant healthy females aged between 24 and 43

Exclusion criteria

Exclusion criteria: Under 24 and over 43 years old females who are pregnant

Design outcomes

Primary

Measure	Time frame
Levels of specific miRNAs isolated from maternal peripheral blood mononuclear cells (PBMCs) in 8-10-week pregnant patients, measured by real-time PCR using TaqMan probes after reverse transcription	—

Secondary

Measure	Time frame
Pregnancy outcome assessed using a questionnaire after 9 months	—

Countries

United Kingdom

Contacts

Public ContactRabi Odia

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026