Ivabradine versus metoprolol for heart rate reduction before coronary computed tomography angiography: a randomised trial

Oral premedication with ivabradine versus metoprolol for heart rate reduction before coronary computed tomography angiography: a randomised trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN74875961

Enrollment

120

Registered

2009-10-01

Start date

2007-03-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary artery disease Circulatory System Chronic ischaemic heart disease

Interventions

Oral medication with 15 mg ivabradine versus 50 mg metoprolol before coronary computed tomography angiography. Drugs were administered once with a one-time follow-up 1 - 3 hours after intervention.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Sinus rhythm 2. Heart rate greater than or equal to 60 bpm 3. Systolic blood pressure greater than or equal to 100 mmHg 4. Aged greater than or equal to 19 years irrespective of gender

Exclusion criteria

Exclusion criteria: 1. Known allergy to iodinated contrast media 2. Impaired renal function (creatinine serum level greater than 1.5 mg/dl) 3. Thyroid disorder 4. Unstable clinical condition 5. Frequent premature heartbeats 6. Sick-sinus-syndrome 7. Sinoatrial block 8. Second or third degree AV-block 9. Previous pacemaker implantation

Design outcomes

Primary

Measure	Time frame
Heart rate reduction 60 - 180 minutes after medication	—

Secondary

Measure	Time frame
Systolic blood pressure before versus after medication	—

Countries

Austria

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026