Danish Alzheimer Intervention StudY

Conditions

Dementia and Alzheimer's disease Nervous System Diseases Dementia in Alzheimer's disease

Rikke Søgaard, Jan Sørensen, Frans Boch Waldorff, Ane Eckermann, Dorte V Buss et al. (7 authors)

BMJ Open2014-01-0125 citations

10.1136/bmjopen-2013-004105

A three-year follow-up on the efficacy of psychosocial interventions for patients with mild dementia and their caregivers: the multicentre, rater-blinded, randomised Danish Alzheimer Intervention Study (DAISY)

Thien Kieu Thi Phung, Frans Boch Waldorff, Dorthe V. Buss, Ane Eckermann, Niels Keiding et al. (12 authors)

BMJ Open2013-11-0179 citations

10.1136/bmjopen-2013-003584

Efficacy of psychosocial intervention in patients with mild Alzheimer's disease: the multicentre, rater blinded, randomised Danish Alzheimer Intervention Study (DAISY).

Waldorff FB, Buss DV, Eckermann A, Rasmussen ML, Keiding N, Rishøj S, Siersma V, Sørensen J, Sørensen LV, Vogel A, Waldemar G.

2012-07-1766 citations

10.1136/bmj.e4693

Private costs almost equal health care costs when intervening in mild Alzheimer's: a cohort study alongside the DAISY trial.

Søgaard R, Sørensen J, Waldorff FB, Eckermann A, Buss DV, Waldemar G.

2009-11-252 citations

10.1186/1472-6963-9-215

Interventions

1. Individualised counselling meetings (fixed and open agendas): 1.1. two meetings with patient and carer (on initiation and towards the end of the intervention), 1.2. two meetings with patient, 1.3.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Progressing degenerative dementia (meeting international criteria for either probable AD, mixed AD/Vascular Dementia [VaD], or Dementia with Lewy Bodies [DLB]) 2. Diagnosis established or confirmed by central specialist unit (memory clinic) in each center 3. Diagnosed within 12 months prior to inclusion 4. Aged above 50 years 5. Mild dementia: Mini-Mental State Examination (MMSE) score of more than 20 6. Primary caregiver (with close contact) who are willing to participate 7. Living at home 8. Sufficient language proficiency in Danish for adequate participation in counselling, interviews and tests 9. Informed consent from patient and caregiver

Exclusion criteria

Exclusion criteria: 1. Severe somatic or psychiatric co-morbidity, including impaired hearing or vision, which will significantly impair cooperation to the program 2. Participation in other intervention studies at inclusion or during the study will not be allowed

Design outcomes

Primary

Measure	Time frame
1. Patient: 1.1. depressive symptoms (Cornell?s depression scale) 1.2. proxy rated health related quality of life (Euro-QoL VAS) 1.3. MMSE 2. Caregiver: 2.1. depressive symptoms (Geriatric Depression Scale, GDS-30) 2.2. health related quality of life (Euro-QoL VAS)	—

Secondary

Measure	Time frame
1. Health related quality of life in patient (patient and proxy rated EuroQoL 5D and VAS, and Quality of life Alzheimer?s disease scale QOL-AD) 2. Health related quality of life in caregiver (EuroQoL 5D and VAS) 3. Behavioral symptoms: Neuropsychiatric Inventory Questionnaire (NPI-Q) 4. Activities of daily living (ADCS-ADL) 5. Insight scale 6. Resource utilisation in patient and carer (Resource Utilisation in Dementia, RUD) 7. Registry-based assessment of health care utilisation and key social and health related events during 12 months before inclusion and during follow-up time (minimum five years): 7.1. time to nursing home, placement and death 7.2. number of in-patient and out patient contacts in patient and carer 7.3. co-morbidity in patient and carer 8. Patient and carer satisfaction with intervention, public services and network questionnaire 9. Patient and carer knowledge and attitudes about key issues in dementia questionnaire	—

Measure

Time frame

1. Health related quality of life in patient (patient and proxy rated EuroQoL 5D and VAS, and Quality of life Alzheimer?s disease scale QOL-AD) 2. Health related quality of life in caregiver (EuroQoL 5D and VAS) 3. Behavioral symptoms: Neuropsychiatric Inventory Questionnaire (NPI-Q) 4. Activities of daily living (ADCS-ADL) 5. Insight scale 6. Resource utilisation in patient and carer (Resource Utilisation in Dementia, RUD) 7. Registry-based assessment of health care utilisation and key social and health related events during 12 months before inclusion and during follow-up time (minimum five years): 7.1. time to nursing home, placement and death 7.2. number of in-patient and out patient contacts in patient and carer 7.3. co-morbidity in patient and carer 8. Patient and carer satisfaction with intervention, public services and network questionnaire 9. Patient and carer knowledge and attitudes about key issues in dementia questionnaire

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Countries

Denmark

Outcome results

None listed