Cambridge Heart Antioxidant Study

Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN74843649

Enrollment

2002

Registered

2004-01-23

Start date

1992-10-10

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular diseases: Heart disease Circulatory System Heart disease

Interventions

Alpha-tocopherol 800 IU daily for first 546 patients, alpha-tocopherol 400 IU daily for remainder versus placebo

Eligibility

Inclusion criteria

Inclusion criteria: Patients with angiographically proven coronary atherosclerosis

Exclusion criteria

Exclusion criteria: Not provided at time of registration

Design outcomes

Primary

Measure	Time frame
Cardiovascular death and non-fatal MI as well as non-fatal MI alone	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026