Inhibitory control in patients with obsessive compulsive disorder Mental and Behavioural Disorders
Conditions
Interventions
The participant was randomly (by computer program) allocated to one of the two groups: a) active 20Hz ACDC TMS, 100% of motor threshold, 40 trains, 50 pulses per train, 18 minutes duration
1 session
b) sham ACDC TMS with a sham coil applied either to mPFC
1 session. Right after the stimulation: EEG with Stroop task and side effect assessment took place.
Sponsors
Charles University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Male and female inpatients or outpatients from the daycare center entering six-week CBT at age 18-70 years 2. Meet DSM-V criteria for OCD as determined by Structured Clinical Interview for DSM-5 (SCID-5) 3. The mental ability to understand and sign Informed Consent Form 4. Being on a stable and adequate dose of antidepressants and/or antipsychotics (monotherapy or combination) for atleast one week prior to enrolment and if clinically appropriate to continue on an unchanged dose of medication during the trial
Exclusion criteria
Exclusion criteria: 1. Psychiatric comorbidity on axis I and II according to DSM V in six months before enrollment to the study 2. Personality disorder that makes participation in the trial difficult 3. History of substance dependence in the last year except nicotine 4. Contraindications of rTMS (history of epilepsy or any neurologic condition likely to increase risk of seizure, mass brain lesions, cerebrovascular accident, metal in the head, a history of major head trauma with unconsciousness longer than 5 minutes) 5. Pregnancy or breast-feeding 6. Patients with severe somatic disorders (cardiovascular disease, neoplasms, endocrinology disorders etc.) 7. Patients treated with electroconvulsive therapy less than 3 months before enrollment or suffering from neurologic disorder (e.g., epilepsy, head trauma with loss of consciousness) and patients using any treatment which can strongly affect EEG 8. Substantial suicidal risk as judged by the treating psychiatrist 9. Sensory and motor impairment precluding the participation in computer tests
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Inhibitory control measured via the interference effect in the Stroop task, measured as the reaction time to incongruent minus the reaction time to congruent stimuli right after the active and sham ACDC TMS stimulation | — |
Secondary
| Measure | Time frame |
|---|---|
| Measured right after the active and sham ACDC TMS stimulation: 1. Inhibitory control measured via the reaction times change and error count in the Stroop task (as less sensitive markers) 2. Electrophysiological effect of the active and sham ACDC TMS stimulation measured using EEG | — |
Countries
Czech Republic
Contacts
Public ContactOlga Laskov
Outcome results
None listed