Immune thrombocytopenic purpura or thrombocytopenia due to bone marrow failure Haematological Disorders
Conditions
Interventions
Platelet function will be tested on blood donated by patients. These tests will be repeated after addition of intermediate purity factor VIII.
Sponsors
NHS Blood and Transplant
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age 18 years or over 2. Confirmed diagnosis of immune thrombocytopenic purpura or a bone marrow failure syndrome such as myelodysplastic syndrome 3. Platelet count less than 50x10^9/l
Exclusion criteria
Exclusion criteria: 1. Any inherited platelet disorder or von Willebrand disease 2. Use of an antiplatelet agent (e.g. aspirin or clopidogrel) in the 7 days before blood sampling
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Normalisation of platelet function, measured with a platelet function analyser 200 adenosine diphosphate/collagen cartridge after addition of intermediate purity factor VIII | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Normalisation of platelet function, measured with microfluidics using collagen as an agonist under arterial shear force conditions after addition of intermediate purity factor VIII 2. Normalisation of platelet function, measured with a platelet function analyser 200 P2Y2 cartridge after addition of intermediate purity factor VIII | — |
Countries
United Kingdom
Contacts
Public ContactMichael Desborough
Outcome results
None listed