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Liverpool Experimental Cancer Medicine Centre biomarker discovery programme

Liverpool Experimental Cancer Medicine Centre (LECMC) biomarker discovery programme and prospective sample collection

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ISRCTN
Registry ID
ISRCTN74588872
Enrollment
1500
Registered
2019-12-10
Start date
2020-01-01
Completion date
Unknown
Last updated
2025-02-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pancreas, head and neck, breast, hepatobiliary and lung cancers Cancer

Interventions

Current interventions as of 09/11/2023: Methodology depends upon the research strand in question and the specific condition that the patient has. However, for every visit for each part of the programm
and is recruited to the programme. 2. Pre-surgical samples taken - blood and saliva. 3. Samples recovered from archive (where available) - tissue. 4. Intra-su

Sponsors

University of Liverpool
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: This will vary according to tumour type. In general, the populations will consist of patients undergoing standard diagnosis and treatment for malignancies and premalignant disease in disease areas which are of interest to the LECMC. All patients must, in addition to fulfilling the medical requirements, complete an informed consent procedure including the physical signing of a consent form. Head and Neck: Presumptive or acute diagnosis of head and neck squamous cell cancer (HNSCC) or recognised oral premalignant conditions (OPML) including but not exhaustively oral epithelial dysplasia (OED), proliferative verrucous leucoplakia (PVL), and those individuals who have been treated for these conditions in the past. Pancreas: All patients with suspected or actual diagnosed Pancreatic Ductal Adenocarcinoma (PDAC), and those individuals who are undergoing or have been treated for PDAC in the past. Breast: Samples from all patients with histologically and/or cytologically confirmed early, locally advanced or metastatic breast cancer including patients with central nervous system (CNS) involvement defined as metastases to the brain parenchyma, metastases to the leptomeninges and/or paraneoplastic disorders. Added 09/11/2023: Hepatobiliary: All patients with suspected or actual diagnosis of primary or secondary hepatobiliary malignancy. Thoracic: Presumptive, past or actual diagnosis of lung cancer, thymic malignancy or mesothelioma, and those individuals who have been treated for these conditions in the past.

Exclusion criteria

Exclusion criteria: 1. Individuals who are unable to consent 2. Under 18 years of age 3. Unable to read or translate patient information sheet and/or consent form

Design outcomes

Primary

MeasureTime frame
The primary outcome measure for this programme will be the number of publications produced by research projects supported by the programme. Each project supported by the programme will have its own outcome measures which will be considered by the programme management team during the project adoption process.

Secondary

MeasureTime frame
There are no secondary outcome measures

Countries

England, United Kingdom

Contacts

Public ContactSara Martin
livecmc@liverpool.ac.uk+44 (0)151 794 8333

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026