Clinical evidence of or high suspicion of multiple trauma Injury, Occupational Diseases, Poisoning Trauma
Conditions
Interventions
Cohort 1: Normal-dose single-pass, whole-body MDCT
Cohort 2: Low-dose, single-pass, whole-body 128-row multi-detector computed tomography (MDCT) with iDose image processing algorithm.
Sponsors
Emergency Hospital, Berlin (Unfallkrankenhaus Berlin) (Germany)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: We will collect data of all consecutive male and female patients of any age who: 1. Had been exposed to a high-velocity trauma mechanism (e.g., car crash, fall from height) 2. Present with clinical evidence or high suspicion of multiple trauma (predicted Injury Severity Score [ISS] =16) 3. Re scheduled for primary, single-pass whole-body MDCT based on the decision of the trauma leader on call
Exclusion criteria
Exclusion criteria: We will exclude patients who, at any time, withdraw consent of study participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Incidence of delayed diagnosis and delayed therapeutically relevant diagnosis until discharge. Co-primary outcome: Diagnostic accuracy (in terms of sensitivity, specificity, positive and negative predictive value), as correlated to the reference standard of a synopsis of all subsequent clinical, imaging, surgical and autopsy findings. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Patient? safety 2. Radiation exposure (e.g. effective dose, volume CT dose index, dose-length-product) 3. General image quality (as independently assessed by two expert radiologists on a 100-mm visual analogue scale [VAS]) 4. Objective image quality (e.g., contrast-to-noise ratio) 5. RNA/DNA instability/damage (to be used as a surrogate parameter) | — |
Countries
Germany
Outcome results
None listed