Acute stroke Circulatory System Cerebrovascular diseases
Conditions
Interventions
Treatment with high dose paracetamol (6 g/day) or placebo will start within 12 hours after onset of symptoms, and continue for three days.
Sponsors
Erasmus Medical Center (The Netherlands)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Clinical diagnosis of acute stroke 2. Possibility to start treatment within 12 hours from onset 3. Brain Computed Tomography (CT) or Magnetic Resonance Imaging (MRI) within 24 hours 4. Age 18 years or older 5. Signed informed consent
Exclusion criteria
Exclusion criteria: Abody temperature lower than 36¡ãC or higher than 39¡ãC A history of liver disease Alcohol abuse 1. Liver enzymes increased above twice the upper limit of normal 2. Allergy to paracetamol 3. Significant pre-stroke impairment (more than three on the modified Rankin Scale [mRS])
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dichotomised mRS (less than or equal to two: good outcome, more than or equal to six: poor outcome) at three months. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Score on the Barthel index after two weeks 2. Body temperature after 24 hours of treatment 3. EuroQol-5D instrument at three months | — |
Countries
Netherlands
Outcome results
None listed