Air pollution & respiratory problems Not Applicable Respiratory disorder, unspecified
Conditions
Interventions
The intervention consists of wearing a R95 particulate respirator (3M, 9900 series) on assigned days for a 2-week period. All volunteers start at the same time and will be randomly allocated to a spec
Sponsors
University of Oxford (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Healthy male and female Vietnamese volunteers over 18 years of age
Exclusion criteria
Exclusion criteria: 1. Smoking tobacco 2. Cooking at home with biomass fuel 3. Not willing to stop eating grilled food during study period of 2 weeks 4. Home address is at a main city road 5. Not willing to wear a face mask 6. Type of work prohibits wearing a mask (e.g. regular conversation) 7. No direct access to mobile phone 8. Not able to read or write 9. Not able to complete the study for other reasons 10. Respirator mask does not fit (determined by fitness test) 11. No informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Concentration of exhaust and smoking metabolites in urine, with 1-hydroxypyrene as the primary endpoint metabolite. Outcomes will be measured at day 0 (baseline), day 4, day 7, day 11 and day 14. | — |
Secondary
| Measure | Time frame |
|---|---|
| Other metabolites in the urine including 1-hydroxynaphthalene, 2-hydroxynaphthalene, 2-hydroxyfluorene, 3-hydroxyfluorene, 9-hydroxyfluorene, 1-hydroxyphenanthrene, 2-hydroxyphenanthrene, 3-hydroxyphenanthrene, 4-hydroxyphenanthrene, Cotinine and Creatinine. Outcomes will be measured at day 0 (baseline), day 4, day 7, day 11 and day 14. | — |
Countries
Viet Nam
Outcome results
None listed