Obesity, blood glucose and lipids Nutritional, Metabolic, Endocrine Other nutritional deficiencies
Conditions
Interventions
Eligible subjects were first sorted by age and then randomized into two groups with a block size of 2, with random numbers generated by statistical software SPSS.
The subjects in the calcium supplem
Sponsors
Harbin Medical University (China)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Aged 30-60 years, healthy female 2. Stable body weight during 6 months before the study
Exclusion criteria
Exclusion criteria: 1. A history of cerebrovascular, cardiovascular, renal, hepatic, diabetes, or other medical diseases likely to interfere with the study 2. Taking medications, which were likely to interfere with the study 3. Received calcium supplements at least for one year before the beginning of the study 4. Pregnant or breast-feeding 5. Information incompleted or unwillingness to attempt to comply with the intervention
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. The effects of calcium supplementation on glucose metabolism: fasting glucose and insulin, 2-hour post prandial glucose, Homeostasis Model of Assessment - Insulin Resistance (HOMA-IR) and glycated hemoglobin (HbA1c) (%) 2. The effects of calcium supplementation on lipids metabolism: 2.1. Serum cholesterol, Triglyceride, HDL cholesterol (HDL-C), low-density-lipoprotein cholesterol (LDL-C), apolipoprotein A-I (Apo A-I) and Apolipoprotein B (Apo B) 2.2. Serum lipoprotein lipase (LPL) and adipocyte fatty acid-binding protein (AFABP) 2.3. Serum free fatty acid (FFA) profile 3. The effect on obesity: anthropometric indexes 4. Serum calcium relative indexes, including parathyroid hormone (PTH), 1.25-hydroxyvitamin D3, serum calcium, thyrocalcitonin and serum phosphate | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Baseline characteristics: age, gender, body mass index (BMI), blood pressure and physical activity level 2. Daily intake of nutrients by the subjects at baseline and after 1 year intervention 3. Blood biochemistry characteristics of the subjects at baseline and after 1-year intervention: red blood cell, white blood cell, hemoglobin, total protein, albumin, urea nitrogen, creatinine, alanine transaminase and aspartate transaminase | — |
Countries
China
Outcome results
None listed