To determine whether a targeted application of dimeticone has a higher efficacy to cure tungiasis (sand flea disease) than wetting the whole feet

Treatment of TUNGiasis (jiggers) with a targeted Application of a two-component DIMETicone

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN74306878

Enrollment

Registered

2014-02-18

Start date

2014-03-01

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tungiasis (sand flea disease) Infections and Infestations Tungiasis

Interventions

The left and the right foot of each participant are randomized to either receive the standard treatment (wetting the foot with dimeticone 3 times during 10 minutes) or the targeted treatment: applicat

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. School children between 6 and 15 years with at least two viable sand fleas in the skin of each foot 2. Care-takers are requested to sign an informed written consent form for the participant before admission

Exclusion criteria

Exclusion criteria: Children with severe bacterial superinfection of tungiasis lesions are not eligible and will be referred to the next primary health care center for antibiotic treatment

Design outcomes

Primary

Measure	Time frame
1. % of viable parasites that died after the application of dimeticone. Viability is determined with a portable digital video microscope. 2. % of parasites that did not develop in a normal manner Followed up daily during 7 days	—

Secondary

Measure	Time frame
Regression of the intensity of local inflammation	—

Countries

Uganda

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 10, 2026