A trial comparing conventional fractionation with 'CHART' in the radical treatment of non-small cell carcinoma of the bronchus

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN74298211

Enrollment

600

Registered

2001-02-28

Start date

1990-02-01

Completion date

Unknown

Last updated

2019-11-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer Cancer Non-small cell carcinoma of the bronchus

Interventions

1. Conventional radiotherapy arm - 2 Gy, once daily five days a week over six weeks (large volume - 44 Gy in 22 fractions followed by small volume - 16 Gy in eight fractions) 2. CHART

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inoperable non-small cell carcinoma of the bronchus confined to the thorax proven by histology or by unequivocal brush cytology

Exclusion criteria

Exclusion criteria: 1. There should be no evidence of distant metastases including supraclavicular nodes; 2. The patient must have no evidence of a pleural effusion unless it can be attributed to a recent surgical intervention; 3. The volume of the site of tumour within the thorax should be such that a radical course of radiotherapy could be given without prejudicing vital structures such as the spinal cord or lung

Design outcomes

Primary

Measure	Time frame
Survival, Local tumour control, Morbidity	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026