Respiratory distress syndrome in preterm babies Respiratory Respiratory distress syndrome
Conditions
Interventions
The intervention arm would receive pressure supported mechanical breaths for all the spontaneous breaths generated by the infant and the control arm would receive SIMV mode of respiratory support as i
Sponsors
North Tees and Hartlepool NHS Foundation Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Preterm infants with RDS, stratified into three groups (23+0 to 25+6, 26+0 to 28+6 and 29+0 to 31+6 weeks) based on their gestation at birth would be enrolled if they are needing mechanical ventilation through an endotracheal tube for at least 6 hours 2. Signed parental consent is obtained before randomisation
Exclusion criteria
Exclusion criteria: 1. Severe congenital malformation 2. Neuromuscular disorder demonstrated clinically with decreased muscular tone 3. Upper airway anomaly 4. Infants transferred from other unit who have met the study entry criteria on admission to the neonatal unit
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is duration of weaning on mechanical ventilation - defined as time from commencing weaning in the assigned mode of respiratory support to the time when the infant is ready for extuabtion demonstrated by passing the MVT | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Total duration of mechanical support through the endotracheal (ET) tube 2. Total duration of respiratory support including non invasive respiratory support 3. Discharge on home oxygen 4. Complications of prematurity | — |
Countries
United Kingdom
Outcome results
None listed