Cerebral palsy Nervous System Diseases Cerebral palsy
Conditions
Interventions
Setting: Testing will take place in either Oxford Brookes University, University of Oxford, Brunel University (or approved research site), London or at the child's school.
Recruitment: Considering a
Sponsors
Oxford Brookes University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Diagnosis of cerebral palsy 2. Ages 10-16 3. Gross motor function classification score I-III 4. Manual ability classification score I-III 5. Upper and/or lower limb impairment
Exclusion criteria
Exclusion criteria: 1. Contraindications to TDCS (e.g. pacemakers, metallic implants in the head or neck, pregnancy, seizures within the past 2 years) 2. Inability to understand instructions and actively participate in the motor training Additional exclusion criteria apply for the optional MRI substudy, such as the presence of non MR-compatible metallic implants. Participants who are excluded from MRI will still be able to undergo all other aspects of the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Hand function measured as performance time for the Jebsen Taylor hand test at baseline and 1 week post-intervention 2. Performance time for the instrumented Timed Up and Go test at baseline and 1 week post-intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Hand function measured using the Jebsen Taylor hand test (time, in seconds) at baseline, 6 weeks post-intervention and 3 months post-intervention 2. Lower limb function measured using the Timed Up and Go (time, in seconds) at baseline, 6 weeks post-intervention and 3 months post-intervention 3. Bimanual hand use measured using the Assisting Hand Assessment at baseline, 1 week, 6 weeks and 3 months post-intervention 4. Spasticity measured using the Modified Ashworth Scale at baseline and 1 week post-intervention 5. Mirror movements measured using the Woods and Teuber scale at baseline and 1 week post-intervention 6. Performance in activities of daily living assessed using the Gait outcomes assessment list at baseline, 1 week, 6 weeks and 3 months post-intervention 7. Hand use measured using the Children’s hand use experience questionnaire at baseline, 1 week, 6 weeks and 3 months post-intervention Other measures: Corticospinal tract integrity assessed using a diffusion-weighted MRI scan at baseline, to test for correlations with change in functional measures | — |
Countries
England, United Kingdom
Outcome results
None listed