Prevention of tuberculosis in people living with HIV infection Infections and Infestations Tuberculosis
Conditions
Interventions
Eligible People Living with HIV (PLHIV) are allocated to the interventional group and the control group by a simple random allocation. This is done by an independent statistician with the help of a co
Sponsors
Public Health Foundation of India
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age 18 - 65 years irrespective of gender 2. Documented HIV diagnosis 3. PLHIV on antiretroviral treatment and stable 4. Received or completed isoniazid prophylaxis therapy 5. Physically fit to perform yoga therapy as self-assessed 6. Written informed consent
Exclusion criteria
Exclusion criteria: 1. Pregnant 2. Seriously ill or moribund PLHIV 3. Practicing yoga therapy >150 minutes/week 4. COVID-19 positive patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Occurrence of tuberculosis among PLHIV, diagnosed by Nucleic Acid Amplification test (NAAT), or sputum smear microscopy or chest X-ray when a PLHIV has a presumptive TB as evident by positive 4S symptom screening consisting of cough, fever, weight loss or night sweat, presence of any one irrespective of duration. 2. CD4 T cell count measured by flow cytometry methods at baseline, 6, 12, 18, and 24 months 3. Viral load measured using real time PCR at baseline, 6, 12, 18, and 24 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Proportion of opportunistic infections other than tuberculosis, measured by taking clinical history at baseline, 6,12, 18 and 24 months 2. Treatment outcome of the diagnosed TB cases amongst PLHIV, measured by sputum smear microscopy at the end of the intensive phase of anti TB treatment and at the end of continuation phase of anti TB treatment | — |
Countries
India
Outcome results
None listed