Effect of a cream containing hyaluronic acid and bacterial wall extract on skin bacterial flora in subjects with facial seborrheic dermatitis

Effects of a cream containing 5% hyaluronic acid conjugated with bacterial wall extract on signs and symptoms and on skin microbiota in subjects with seborrheic dermatitis of the face

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN74021432

Enrollment

Registered

2018-11-08

Start date

2017-04-01

Completion date

Unknown

Last updated

2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Seborrheic dermatitis of the face Skin and Connective Tissue Diseases Seborrheic dermatitis of the face

Interventions

Participants will be provided with a cosmetic cream containing hyaluronic acid 5%, bacterial wall ferment, zinc PCA, climbazole, piroctone and glycyrrhetinic acid, to be used twice daily on the face (

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged 20 years or older 2. Clinical diagnosis of moderate or severe seborrheic dermatitis 3. Written informed consent

Exclusion criteria

Exclusion criteria: 1. HIV positive 2. Specific oral or topical treatments for seborrheic dermatitis (SD) in the previous 4 weeks 3. Pregnancy or breastfeeding 4. Known allergies to one or more component of the tested cream 5. Other inflammatory skin conditions other than SD 6. Use of oral probiotics in the previous 6 weeks 7. Cigarette smoking

Design outcomes

Primary

Measure	Time frame
The Investigator Global Assessment (IGA) is used at the baseline, week 3 and week 6 to assess the following: 1. Erythema 2. Seborrhea 3. Itching	—

Secondary

Measure	Time frame
Evolution of superficial facial microbiota in the following areas: 1. Interglabellar 2. Naso-labial fold 3. Mandibular rim This was assessed using 16Sr RNA gene sequencing at the baseline and after 6 weeks. Samples for RNA sequencing were obtained The samples for RNA sequencing were obtained with Dry swabbing . Sample were taken in 3 different areas for each subject: Zone 2 Glabellar ; zone 2: nasolabial fold; Zone 3: mandibular rim. Swabs were stored a -80 C until the tests Dry swab samples of the following areas were taken to assess superficial facial microbiota using 16S rRNA gene sequencing at the baseline and after 6 weeks: 1. Interglabellar 2. Nasolabial fold 3	—

Measure

Time frame

Evolution of superficial facial microbiota in the following areas: 1. Interglabellar 2. Naso-labial fold 3. Mandibular rim This was assessed using 16Sr RNA gene sequencing at the baseline and after 6 weeks. Samples for RNA sequencing were obtained The samples for RNA sequencing were obtained with Dry swabbing . Sample were taken in 3 different areas for each subject: Zone 2 Glabellar ; zone 2: nasolabial fold; Zone 3: mandibular rim. Swabs were stored a -80 C until the tests Dry swab samples of the following areas were taken to assess superficial facial microbiota using 16S rRNA gene sequencing at the baseline and after 6 weeks: 1. Interglabellar 2. Nasolabial fold 3

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Countries

Italy

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026