Ischaemia Circulatory System Transient ischaemic attack
Conditions
Interventions
Secondary prevention after transient ischaemic attack or non-disabling ischaemic stroke.
Three treatment strategies:
1. Oral anticoagulation (international normalised
Sponsors
University Medical Center Utrecht (Netherlands)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients presenting in the participating hospitals with a transient ischaemic attack (TIA) or non-disabling stroke of atherosclerotic origin 2. Randomisation within 6 months after the TIA or minor stroke 3. Modified Rankin scale of 3 or less
Exclusion criteria
Exclusion criteria: 1. (Contra)indication to, or intolerance to, anticoagulants, dipyridamole, or aspirin 2. Disease expected to cause death within weeks or months 3. Source of embolism in the heart 4. Moderate or severe ischemic damage to the white matter of the brain (leukoaraiosis) 5. Anemia, polycythemia, thrombocytosis, or thrombocytopenia 6. Planned carotid endarterectomy 7. Intracranial bleeding or cerebral tumour 8. TIA or stroke caused by vasculitis, migraine, or dissection 9. Severe hypertension 10. Liver failure 11. Pregnancy 12. Chronic alcohol abuse
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Composite of death from all vascular causes, non-fatal stroke, non-fatal myocardial infarction, or major bleeding complication, whichever happened first. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Death from all causes 2. Death from vascular causes 3. Death from vascular causes or nonfatal stroke 4. Fatal or nonfatal stroke 5. Death from vascular causes, nonfatal stroke, nonfatal myocardial infarction or vascular intervention 6. Major bleeding complications 7. Amputations of lower extremities 8. Retinal infarction or bleeding | — |
Countries
Netherlands
Outcome results
None listed