Xylitol Clinical Studies for Prevention - Xylitol Dose Study (Gum 1)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN73818624

Enrollment

132

Registered

2005-12-02

Start date

2003-03-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental Caries Oral Health Dental caries

Interventions

4 group design. Control (sorbitol gum) and 3 xylitol gum groups all chewed 12 pellets of gum evenly divided into 4 times per day.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Adult, male & female, with screening plaque mutans streptococci level greater than 10,000 CFU/ml

Exclusion criteria

Exclusion criteria: 1. Gastro-intestinal diseases/problems 2. Phenylalanine intolerant

Design outcomes

Primary

Measure	Time frame
Reduction in mutans streptococci level in plaque and saliva	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United States of America

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026