Schizophrenia and other psychoses Mental and Behavioural Disorders Schizophrenia
Conditions
Interventions
1. Experimental group: will receive care from the Early Psychosis Service (a multi professional Assertive Community Treatment team targeted at people suffering their first or second episode of psychot
Sponsors
NHS R&D Regional Programme Register - Department of Health (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 16 - 35 years 2. Living in the catchment areas served by the team (pop. approx 150,000) 3. Presenting with a first or second episode of a psychotic disorder (International Statistical Classification of Diseases and Related Health Problems, tenth edition [ICD-10] schizophrenia spectrum disorder including unspecified non-organic psychosis) Every effort will be made to include as many eligible patients as possible. For example, assistance of interpreters associated with the clinical service will be enlisted in order to include patients whose first language is not English..
Exclusion criteria
Exclusion criteria: Patients with primary substance use disorder will not be eligible for the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Relapse, readmission and detention at 18 months. We define relapse as any case noted record of a change in clinical state that has resulted in an increase in psychotrophic medication and/or an admission to hospital. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measures will include a range of clinical social and service use outcomes: 1. Clinical measures at all three time points: 1.1. Brief psychiatric rating scale (BPRS) 1.2. Positive and negative syndrome scale (PANSS) 1.3. Global Assessment of Functioning (GAF) scale 1.4. Calgary Depression Scale 1.5. Insight Scale 1.6. Treatment compliance at 6 and 18 months 2. Social functioning at all three time points: 2.1. Employment status 2.2. Housing status 2.3. Benefit uptake 2.4. Social network scale 2.5. Life Skills Profile (LSP) 3. Patient and carer satisfaction/burden: 3.1. Verona satisfaction scale 3.2. Family burden at 18 months 4. Service use and costs: assessed retrospectively at 18 months based on a combination of service records and a standard instrument - the Client Service Receipt Inventory. Resource use will be identified for both treatment and control group and will include: 4.1. Medication costs 4.2. NHS services 4.3. Local authority services accommodation 4.4. Contact with criminal justice and all other services 4.5. Indirect economic impacts (particularly lost employment and caregiver burden) will also be included. 5. Team process measures and fidelity - team activity logs e.g.: 5.1. Contacts per client 5.2. Out of hours contacts 5.3. Interventions offered 5.4. Adherence to ACT model | — |
Countries
United Kingdom
Outcome results
None listed