Dengue Infections and Infestations Dengue
Conditions
Interventions
Current intervention as of 11/12/2018:
Following 12 months of baseline data collection (this includes epidemiological and entomological data), household intervention begins in the selected interventio
Sponsors
Norwegian University of Life Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Village: Within ring roads of each strata (city), populated residential areas. Cluster: All points of the cluster are at least 100 m from the nearest point of the village border. Household: 1. Households that are permanently inhabited 2. Households that are built or re-populated during the study period Individuals: 1. In households where household head has signed informed consent for household to participate in project 2. A travel history outside the village during the previous 7 days 3. Chronic diseases such as HIV/AIDS or cancer 4. Apparent inability to give informed consent, e.g., due to mental disability or other incapacity, or lack of a legally authorized representative 5. Disease with similar symptoms to dengue but with evident alternative explanation 6. Age >1 year old
Exclusion criteria
Exclusion criteria: Village: 1. Area <0.125 km2 2. Number of houses<100 3. Population <300 4. Coverage of residential area 70-80% (scattered housing) 5. Non-residential areas, e.g. agricultural fields, airport, industrial areas, commercial areas, (e.g. shopping malls), government offices, lakes. army camps, hospitals and schools. Household: 1. Apartment buildings 2. Abandoned houses 3. Non-permanent households Individual 1. Refusal to participate in the study 2. Age <1 year old
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Adult Index (AI), is measured by collecting the number of adult female Ae. aegypti and Ae. albopictus per house (combined species) collected both indoors and outdoors for 15 minutes each location (30 minute total collection time) using a battery-driven mechanical aspirator. Collections occur once every four months in all households and once every month in three repeat sentinel households per cluster. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Dengue Incidence Rate (DIR) is measured by the number of confirmed dengue cases divided by observation-days of household populations by identifying all household members with a fever at weekly VHV visits in participating households. Confirmed dengue cases are those fever patients with a positive RDT and a subsequent laboratory RT-PCR. 2. Mosquito Exposure Index (MEI) is measured using the proportion of blood samples with prescence of IgG antibodies to Ae. aegypti Nterm-34kDa salivary peptide, using immunoassays through blood samples taken from two persons per household at every four months in all households, once every month in three repeat sentinel households per cluster, and from fever cases detected during the weekly visits. 3. Infected Adult Index (IAI) is measured using the number of DENV infected adult female Ae. aegypti and Ae. albopictus per house (combined species) both indoors and outdoors for 15 minutes each using a battery-driven mechanical aspirator. DENV presence will be confirmed by real time RT-PCR. 4. Adult Sticky Trap Index (ASTI) is measured using the number of adult female Ae. aegypti and Ae. albopictus (combined species) outdoors each month using one sticky trap per house baited with an oviposition attractant hay infusion in four selected households for 7 consecutive days per month 5. Pupae/Person Index (PPI) is measured using the total number of Aedes pupae by collecting the amount of participating households divided by the number of persons in that household at once every four months in all households and once every month in three repeat sentinel households per cluster 6. Breteau Index (BI) is measured using the number of immature Aedes positive containers per 100 houses measured at the cluster level, at once every 4 months in all households and once every month in three repeat sentinel households per cluster | — |
Countries
Thailand
Outcome results
None listed