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Zinc supplementation during acute childhood diarrhoea: a cluster randomised trial in rural Pakistan

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN73387335
Enrollment
5000
Registered
2005-02-10
Start date
2005-01-26
Completion date
Unknown
Last updated
2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Childhood diarrhoea Infections and Infestations Non-chronic diarrhoea

Interventions

Administration of 10 to 20 mg elemental zinc daily through oral rehydration versus the existing program of oral rehydration alone in management of acute diarrhoea for 14 days. No placebo is being used

Sponsors

The Department of Child and Adolescent Health (CAH)/World Health Organization (WHO) (Switzerland)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Children with diarrhoea from 6 to 59 months and 2 to 6 months presenting to any health care facility including both public and private 2. Informed consent

Exclusion criteria

Exclusion criteria: 1. Chronic and recurrent diarrhoea 2. Children less then 2 months or above 5 years

Design outcomes

Primary

MeasureTime frame
1. ORS use rate 2. Antibiotic use rate 3. Overall drug use rate for diarrhoea 4. Incidence/prevalence of diarrhoea 5. Duration of diarrhoea/episodes in days 6. Duration of use of ORS, antibiotics and zinc 7. Prevalence /incidence of vomiting 8. Hospitalisation rate for diarrhoea 9. Hospitalisation rate for all causes 10. Total expenditure per household and per episode of diarrhoea

Secondary

MeasureTime frame
No secondary outcome measures

Countries

Pakistan

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026