Anaesthesia requirement Surgery
Conditions
Interventions
08/07/2013: Please note that this trial has been terminated.
The recruitment was slow, also two recent publications on the same topic have answered the question we were investigating, so there was no
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Doufas AG, et al. Anesth Analg 2013
116:319
Potential participants should have naturally red scalp hair, and ?pale? or ?fair? skin which tans poorly in response to UVR.
Interventions:
1. Measurement of bispectral index (BIS) after 15
Sponsors
University Hospital Southampton NHS Foundation Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Males or females 2. Aged between 30 and 50 years of age 3. Are presenting for elective surgery 4. Able to give informed consent 5. Subjects will be American Society of Anesthesiologists (ASA) physical status grade I or II (healthy or with minor / controlled systemic disease) 6. To avoid bias from background population genetics, all subjects will be Caucasian, and of Northern European dissent by self-identification 7. Potential participants should have naturally red scalp hair, and ?pale? or ?fair? skin which tans poorly in response to ultraviolet radiation (UVR). 8. The control group is of individuals with brown or black scalp hair who tan easily in response to UVR (e.g. after frequent sunbathing during an entire summer)
Exclusion criteria
Exclusion criteria: 1. Patients who are taking any of the following as these drugs may modify the response to anaesthesia and the pain reflex: 1.1. Sedatives 1.2. Strong opioid pre-medication 1.3. Regular opioid analgesics 1.4. Psychotropics 1.5. Anti-convulsants 1.6. Recreational drugs of abuse (amphetamines, cocaine, benzodiazepines, opioids, or alcohol excess) 2. If a general anaesthetic has been administered within the last 6 weeks 3. If the patient has possibly built up tolerance to the anaesthetic 4. Subjects who are pregnant 5. Subjects with a body mass index (BMI) greater than 35 kg/m2 6. Subjects with a known allergy or reaction to anaesthetics 7. Subjects with uncontrolled systemic disease (including chronic pain syndrome and heart burn) 8. Recent involvement in other research unless it can be demonstrated that there will be no possible effect or interaction resulting from the existing trial interventions, and permission can be obtained from the sponsor
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The difference in bispectral index (BIS) score between groups | — |
Secondary
| Measure | Time frame |
|---|---|
| Frequency (percentage) movement in response to noxious stimulus while under anaesthesia | — |
Countries
United Kingdom
Outcome results
None listed