A comparison of the effects of rofecoxib and diclofenac on the PFA-100, a laboratory based indicator of platelet function, in a post-operative neurosurgical population

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN73370863

Enrollment

Registered

2003-09-12

Start date

2002-06-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Platelet dysfunction Haematological Disorders Purpura and other haemorrhagic conditions

Interventions

1. Rofecoxib 2. Diclofenac This trial was stopped in September 2003 due to participant recruitment issues.

Eligibility

Inclusion criteria

Inclusion criteria: 30 Patients from Neurosurgery/NSITU.

Exclusion criteria

Exclusion criteria: Does not meet inclusion criteria

Design outcomes

Primary

Measure	Time frame
Assessment of comparative effects of COX I/COX II inhibitors on platelet function using the platelet function analyser, the PFA-100, on blood samples taken from the participants.	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026