Atomisation inhalation for patients undergoing non-mechanical ventilation with endotracheal intubation Injury, Occupational Diseases, Poisoning
Conditions
Interventions
Comatose patients undergoing non-mechanical tracheal ventilation were included and divided into two groups: the experimental group (n = 56) and the control group (n = 49). The experimental group was p
Sponsors
Second Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18-88 years old 2. Comatose patients undergoing non-mechanical ventilation with endotracheal intubation 3. Patients whose condition could tolerate atomisation inhalation before an operation 4. Patients whose guardians agreed to participate in this trial and provided written informed consent
Exclusion criteria
Exclusion criteria: 1. Patients with an endotracheal intubation retention time of <5 days 2. Patients who underwent endotracheal intubation and switched to mechanical ventilation on days 1 to 5 3. Patients who underwent mechanical ventilation before switching to non-mechanical ventilation after endotracheal intubation 4. Patients who were intubated and then changed to tracheotomy within 5 days 5. Patients with respiratory failure, heart failure and/or severe liver and kidney diseases 6. Patients with acute respiratory failure or acute renal injury
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The following primary outcome measures were assessed at time points on days 1-5 after humidification: 1. Sputum viscosity is evaluated by clinical doctors based on standardized grading scales 30 minutes after each nebulization session, with assessments carried out twice daily 2. Sputum pH value measured using pH test paper and comparison with the acid-base colorimetric card 30 minutes after each nebulization session, with assessments carried out twice daily | — |
Secondary
| Measure | Time frame |
|---|---|
| The following secondary outcome measures were assessed at time points on days 1-5 after humidification: 1. Airway mucosal bleeding measured by observation of airway mucosal bleeding was conducted 30 minutes after each nebulization session, with assessments carried out twice daily 2. Sputum scab formation measured using data recording observations of resistance during the insertion of the conventional suction catheter, small sputum scabs inside the suction catheter during suctioning and/or sputum scabs on the suction catheter during suctioning 4 hours after each nebulization session, with assessments carried out twice daily 3. Respiratory patency measured using a combination of physical examination, including observation and auscultation, the analysis of capnography and ventilator settings to ensure a comprehensive evaluation of airway obstruction and ease of breathing 4 hours after each nebulization session, with evaluations carried out twice daily 4. Pulmonary infection measured by conducting bedside lung ultrasound assessments at a fixed time each day, specifically at 18:00, to provide more continuous and dynamic monitoring of the patient’s pulmonary infection status | — |
Countries
China
Contacts
Public ContactLiqiao Zhang
Outcome results
None listed