Topic: Reproductive health and childbirth
Conditions
Interventions
1. Embryoscope: Half of the female participant s embryos will be cultured in the Embryoscope
2. MINC benchtop incubator: Half of the female participant s embryos will be cultured in th
Sponsors
Southampton University Hospitals NHS Trust
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Standard indication for IVF/ICSI treatment 2. Good understanding of written and spoken English 3. Female age under 42 4. Antral Follicle Count (AFC) of more than 15 or Anti Mullerian Hormone (AMH) of more than 10pmol/l
Exclusion criteria
Exclusion criteria: 1. Any medical contraindication to IVF/ICSI 2. Previous diagnosis of HIV, Hep B or Hep C 3. High risk of Ovarian Hyperstimulation Syndrome (OHSS) as assessed prior to triggering of final oocyte maturation 4. Less than 6 2PN zygotes or more than 14 2PN zygotes available for culture
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of embryos reaching blastocyst stage in Embryoscope versus MINC benchtop incubator on day 5 after culture in the Embryoscope | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. A comparison of the mean morphology score of embryos from each cohort on day 5 after culture in the Embryoscope versus the MINC incubator 2. Number of embryos suitable for cryopreservation from Embryoscope versus MINC 3. Number of “usable” embryos from Embryoscope versus MINC 4. Implantation rate in relation to metabolic activity of embryo(s) transferred 5. A comparison of the amino acid profile in the conditioned media obtained from blastocysts after culture in the Embryoscope versus the MINC Incubator 6. Correlation between metabolic activity and embryo viability as assessed by morphological and morphokinetic assessment | — |
Countries
England, United Kingdom
Outcome results
None listed