Enteric fever Infections and Infestations Typhoid fever
Conditions
Interventions
The site-specific incidence of enteric fever will be estimated through a hybrid approach - hospital-based surveillance combined with a healthcare utilization survey. Surveillance for enteric fever wil
Sponsors
Vellore Christian Medical College Foundation
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: For the hospital-based surveillance: 1. Age: greater than six months of age 2. Gender: Both 3. Patients presenting with fever who are hospitalized irrespective of the duration of fever or temperature 4. Patients with non-traumatic ileal perforation irrespective of history of fever or culture confirmation of typhoid For the healthcare utilization survey: 1. All those who normally reside and are present in the household during the entire period of survey – from the first day of survey to the last day of survey (both days inclusive). 2. All those who were known to be normally residing and had actually stayed in the household during a part of the survey (from the first day of survey to the last day of survey) but were not present at the time of visit of the interviewer. 3. All those who were known to be normally residing in the household and were not present at the time of visit of the enumerator but are expected to return by the last day of survey. 4. Age: all 5. Gender: both
Exclusion criteria
Exclusion criteria: For the hospital-based surveillance: 1. Patients who are not Indian citizens For the healthcare utilization survey: 1. Visitors to the household
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of enteric fever in each of the study sites over the 24 months of surveillance measured by dividing the number of blood culture-confirmed enteric fever cases with the product of the hospital's catchment population and time period of surveillance. This crude incidence shall then be adjusted for the proportion of febrile patients from the catchment population seeking inpatient healthcare at other facilities, compliance to the study protocol, the sensitivity of blood culture and the probability of enteric fever patients being hospitalized. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Characterization of the clinical spectrum of enteric fever presenting at smaller (<350 beds) hospitals over the 24 months of surveillance- determined through estimating the prevalence of enteric fever among those hospitalized with a febrile illness, the prevalence of complications and severe disease among those presenting to surveillance facilities with enteric fever, and prevalence of antimicrobial resistance among S. Typhi/S. Paratyphi isolates 2. Estimates of the cost of treatment and productivity loss associated with a severe enteric fever over the 24 month period of surveillance- determined through calculating direct and indirect cost-of-illness for severe enteric fever and indebtedness directly attributable to the severe enteric fever illness episodes | — |
Countries
India
Contacts
Public ContactJacob John
Outcome results
None listed