1. Chronic malnutrition 2. Infection by pathogenic intestinal parasites Infections and Infestations 1. Chronic malnutrition 2. Infection by pathogenic intestinal parasites
Conditions
Interventions
After being included in the study, caregivers will be asked about registration name, house name and age of all members of the household, as well as the neighbor of residence and contacts information.
Sponsors
Centro de Investigação em Saúde de Angola - CISA (Health Research Centre of Angola)
Instituto de Higiene e Medicina Tropical
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria of children: 1. Age between 20-36 months at the recruitment period 2. Residents in the Dande Health and Demographic Surveillance System study area 3. No history of antibiotherapy in the previous 10 days 4. Children infected with at least one pathogenic intestinal parasite 5. Informed consent signed by parents or primary caregivers Inclusion criteria of household members (arm 2 and 4): After permission of the caregiver for child to participate in the study, arms 2 and 4 preview the inclusion of all the members of the household. Written Informed consent is required.
Exclusion criteria
Exclusion criteria: Exclusion criteria of children: 1. Age under 20 months or above 36 months 2. Children whom parents or primary caregivers do not reside in the Dande Health – and Demographic Surveillance System study area 3. Children with history of antibiotherapy or antiparasitic drug in the previous 10 days that can lead to false negatives in microscopic identification of pathogenic intestinal parasites 4. Children who are not infected with pathogenic intestinal parasites (protozoa and/or helminths) 5. Children whom parent or primary caregivers do not intend to participate in the study Exclusion criteria for household members (arm 2 and 4): 1. Any person who does not live in the same household of the child included in the study 2. Household member who do not intend to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Linear growth of children is assessed by mean change in height-for-age Zscores from baseline to 4, 8, 12, 16, 20 and 24 months of follow-up period 2. Improvement of weight for height is assessed by mean change in weight-for-height Zscores from baseline to 4, 8, 12, 16, 20 and 24 months of follow-up period 3. Improvement of weight for age of children is assessed by mean change in weight-for-age Zscores from baseline to 4, 8, 12, 16, 20 and 24 months of follow-up period | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Occurrence of infection by intestinal protozoa and helminths measured using stool sample analysis (direct examination with saline and iodine, a concentration method using Parasite Recovery System, kato-katz and kinyoun staining for coccidea diagnosis) from the baseline to 4, 8, 12, 16, 20 and 24 months of follow-up period 2. Occurrence of malaria measured using blood sample analysis from the baseline to 4, 8, 12, 16, 20 and 24 months of follow-up period 3. Improvement of anemia is assessed by mean change in haemoglobin (g/dl) from 4, 8, 12, 16, 20 and 24 months of follow-up period | — |
Countries
Angola
Contacts
Public ContactCarolina Gasparinho
Outcome results
None listed