Critically ill patients Not Applicable
Conditions
Interventions
Each patient will be studied on two consecutive nights (from 9:00 pm to 7:00 am). In each patient two nights polysomnography studies will be performed with or without propofol in random order. Propofo
Sponsors
Cretan Critical Care Society (Greece)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Critically ill patients, on mechanical ventilation for at least 48 hours, haemodynamically stable 2.Ventilated on assist mode 3. No respiratory distress 4. Aged between 18 and 85 years, inclusive, either sex
Exclusion criteria
Exclusion criteria: 1. Aged less than 18 and greater than 85 years 2. Severe haemodynamic instability 3. Pregnancy 4. End stage disease 5. Respiratory distress 6. Acute brain injury
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Effect of propofol on sleep quality, measured immediately after each study night 2. Sleep architecture, scored manually by an expert physician not involved in the study. 3. Central apnoeas, arousals and awakenings, defined using standard criteria 4. Total sleep fragmentation, calculated as the sum of arousals and awakenings per hour of sleep | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
Greece
Outcome results
None listed