Addiction opiate dependence Mental and Behavioural Disorders Opiate addiction
Conditions
Interventions
In accordance with best clinical practice all sites will offer patients the 'super-accelerated vaccination schedule' (comprising three injections at 1, 7 and 21 days) (Department of Health, 2006
2007). The vaccination schedule offered in each site will be identical. The treatment offered will differ only in terms of the absence/presence (and type) of adjunctive incentive schedule as follows:
Sponsors
South London & Maudsley NHS Foundation Trust and Kings College London (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged greater than 18 years, either sex 2. New episode of opiate treatment (within first 2 months) 3. Previous, current, or at risk of engaging in risk behaviour (i.e. injecting drug use) 4. Willing to receive vaccination 5. Willing to provide informed consent
Exclusion criteria
Exclusion criteria: 1. Pregnant or breastfeeding 2. Received prior hepatitis B vaccination course 3. Current or past hepatitis B infection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Successful completion of the three Hep B vaccination injections (days 1, 7 and 21) within 28 days. Participants will be defined as completers if they receive all three injections by day 28. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. On-time attendance 2. For those who do not complete, the proportion of vaccination doses received | — |
Countries
United Kingdom
Outcome results
None listed