Huntington's disease Nervous System Diseases Huntington's disease
Conditions
Interventions
As of 24/06/2009 this record was updated to include information on the updated protocol. Both participants with HD and matched healthy control subjects will also perform, as part of their respiratory
Sponsors
Cardiff University (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: People with Huntington's disease: 1. Both males and females, aged 18 years or older 2. Confirmed diagnosis of HD 3. Able to understand instructions in English Healthy subjects: 1. Age, sex and body mass index (BMI) matched individuals 2. Able to understand instructions in English
Exclusion criteria
Exclusion criteria: Inability to understand English
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Respiratory function including: 1. Forced vital capacity (FVC) 2. Forced expiratory volume in 1 second (FEV1) 3. Forced expiratory ratio (FEV1/FVC) 4. Flow volume loops 5. Sniff nasal inspiratory pressure (SNIP) 6. Maximal inspiratory pressure (PIMax) 7. Maximal expiratory pressure (PEMax) 8. Respiratory muscle endurance (TLim) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Swallow capacity (mls/sec) 2. Perception of respiratory problems Relational outcome measures: 1. Posture: thoracic angle, cervical angle, head tilt 2. Exercise capacity: 6 minute walk test (distance walked in 6 minutes) 3. Functional capacity: Barthel index (questionnaire measuring ability to carry out activities of daily living) | — |
Countries
United Kingdom
Outcome results
None listed