Healthy active population Other
Conditions
Interventions
A single centre interventional double-blind placebo-controlled randomised crossover trial is being used to investigate a novel potassium sensor and the effect of caffeine on cognitive and physical pe
(2) List Sorting Working Memory Test and (3) Oral Symbol Digit Test (3 minutes). Stimuli are presented digitally (on the laptop) but oral responses are given, and the experimenter records the respons
Sponsors
Defence Science and Technology Laboratory
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Male or female 2. Aged 18-35 years 3. Pass UK military physical tests
Exclusion criteria
Exclusion criteria: 1. Any intolerance or avoidance of caffeine 2. Any prescribed medication 3. Smokers (smoking defined as more than 100 cigarettes throughout lifetime) 4. Vaping defined as any use in last 7 days 5. Liquorice consumption within the last 7 days 6. Recreational drug use in the last month, including, but not limited to, cannabis and cocaine 7. Any medical condition that would prevent entry into army, navy or air force 8. Phobia to needles 9. Allergy or insensitivity to materials used in the study (e.g., adhesive) 10. Recent musculoskeletal injury (within the last 3 months) 11. Non-English speakers 12. Pregnancy 13. Atrial fibrillation 14. Any findings that the Clinical research fellow believes affect the integrity of study data or the safety to conduct tests
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Potassium Levels - measured via novel potassium sensor at rest and during exercise via sweat and from blood | — |
Secondary
| Measure | Time frame |
|---|---|
| Effect of caffeine on cognitive and physical performance: 1. Electrodermal activity is measured using electrodes on the hand or wrist at 45 minutes post-administration 2. Attention is measured using the Flanker Inhibitory Control and Attention Test at 45 minutes post-administration 3. Working memory is measured using the List Sorting Working Memory Test at 45 minutes post-administration 4. Reaction time is measured using the Oral Symbol Digit Test at 45 minutes post-administration 5. Breath-by-breath analysis is measured using a Hans-Rudolph mouthpiece and online gas-analysis system during treadmill testing 6. Heart rate is measured using a Polar heart rate chest strap during treadmill testing 7. Gait pattern is measured using the infra-red OptoJump system during treadmill testing 8. Ratings of perceived exertion are measured using the Borg 6-20 scale at 10-minute intervals throughout the marching protocol and at the end of the shuttle runs 9. Glucose is measured using a finger prick capillary blood sample and Biosen EKF point of care glucose/lactate analyser at 10-minute intervals throughout the marching protocol 10. Lactate is measured using a finger prick capillary blood sample and Biosen EKF point of care glucose/lactate analyser at 10-minute intervals throughout the marching protocol 11. Muscle performance is measured using an isokinetic dynamometer before and after the 62-minute treadmill protocol 12. Gas exchange (O2, CO2, minute ventilation) is measured using a Cortex Metalyzer breath-by-breath gas analysis system throughout the marching protocol | — |
Countries
England, United Kingdom
Contacts
Public ContactChristopher Gaffney
Outcome results
None listed