Vitamin D deficiency Nutritional, Metabolic, Endocrine
Conditions
Interventions
This is a trial of low-level UVR exposures in a comparative study of human volunteers in 2 age groups, young (18-40 years) and aged (65-89 years). Volunteers will be matched for other attributes inclu
similar techniques will provide for 25(OH)D analysis of blood samples.
Volunteers will complete a daily diet diary for 1 week and lifestyle questionnaire, as used in previous studies by our group, t
Sponsors
The University of Manchester
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Healthy, ambulant human volunteers 2. Male and female 3. Aged 18-40 or 65-89 years 4. White Caucasian (sun-reactive skin types I-III)
Exclusion criteria
Exclusion criteria: 1. History of photosensitivity disorder or skin cancer 2. Taking photoactive or bone active therapies 3. Sunbathing/sunny holiday/sunbed use in past 3 months 4. Taking vitamin D doses > 200 IU (5 µg) 5. Taking anti-coagulation medicines including Aspirin, Clopidogrel and Warfarin or Propranolol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Skin level of 7-DHC measured by tandem mass spectrometry at baseline and 24 hours post-UVR intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Skin level of pre-vitamin D and vitamin D measured by tandem mass spectrometry at baseline and 24 hours post-UVR intervention 2. Serum 25-hydroxyvitamin D measured by tandem mass spectrometry at baseline and 1 week post-UVR intervention 3. Daily dietary vitamin D intake assessed by diet diary over 1 week | — |
Countries
England, United Kingdom
Contacts
Public ContactLesley Rhodes
Outcome results
None listed