Optimizing epilepsy surgery

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN72646265

Enrollment

300

Registered

2020-09-25

Start date

2020-10-01

Completion date

Unknown

Last updated

2026-03-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epilepsy Nervous System Diseases Epilepsy

Interventions

This programme of research has been developed with the benefit of input from individuals who have had or are considering epilepsy surgery for themselves or a loved one. This is the BrainBuddyUK group

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Considering epilepsy surgery for drug-resistant focal epilepsy, at National Hospital for Neurology and Neurosurgery (NHNN) 2. Any gender, age 18-70 years 3. Has capacity to give informed consent 4. No contra-indication to neurosurgical intervention

Exclusion criteria

Exclusion criteria: 1. Lack of capacity to give informed consent 2. Comorbidities that would make neurosurgical intervention inappropriate (e.g., active neoplasia, cerebrovascular disease, dementia, coagulopathy)

Design outcomes

Primary

Measure	Time frame
Seizure freedom following neurosurgical treatment for refractory focal epilepsy using the Engel classification at pre-operation (baseline), 3 months post-operation, 1 year post-operation	—

Secondary

Measure	Time frame
1. Symptom analysis – measured by the extent of change in the planned implantation of SEEG electrodes from the original clinical data without the symptom analysis (single timepoint) 2. Optimal electrode planning: The time taken to plan a study is measured, as is the safety of the planned implantation (proximity to blood vessels) compared to previous recent data of implantations planned without the use of prior trajectories as a starting point (single timepoint, comparator is historical data) 3. Resection planning: comparison of the resection plan derived from the conventional method used, with the resection plan produced by the image-guided methods (comparison of volume to be resected, single timepoint once both resection plans are made) 4. Complications, causing neurological deficit, following neurosurgical treatment for refractory focal epilepsy, particularly deficits of language and visual fields after temporal lobe resection (formally measured by visual fields testing and language and memory assessments pre-operatively and 3 months post-operatively)	—

Measure

Time frame

1. Symptom analysis – measured by the extent of change in the planned implantation of SEEG electrodes from the original clinical data without the symptom analysis (single timepoint) 2. Optimal electrode planning: The time taken to plan a study is measured, as is the safety of the planned implantation (proximity to blood vessels) compared to previous recent data of implantations planned without the use of prior trajectories as a starting point (single timepoint, comparator is historical data) 3. Resection planning: comparison of the resection plan derived from the conventional method used, with the resection plan produced by the image-guided methods (comparison of volume to be resected, single timepoint once both resection plans are made) 4. Complications, causing neurological deficit, following neurosurgical treatment for refractory focal epilepsy, particularly deficits of language and visual fields after temporal lobe resection (formally measured by visual fields testing and language and memory assessments pre-operatively and 3 months post-operatively)

—

Countries

England, United Kingdom

Contacts

Public ContactJohn Duncan

j.duncan@ucl.ac.uk+44 (0)20 3448 8612

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 27, 2026