Gonarthritis in inflammatory rheumatic disease Musculoskeletal Diseases Gonarthritis
Conditions
Interventions
Single injection of Morphine 3 mg or Dexamethasone 4 mg or Placebo during needle arthroscopy. Rearthroscopy after 7 days.
Sponsors
Charité - University Medicine Berlin (Charité - Universitätsmedizin Berlin) (Germany)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age 19-70 2. Gonarthritis with sonographically evident effusion in inflammatory rheumatic disease 3. Visual analogue score (VAS) pain >30 mm 4. Body weight 50-90 kg 5. Written informed consent
Exclusion criteria
Exclusion criteria: 1. Pregnancy, lactation 2. Severe or opportunistic infection, infection of the knee 3. Malignant diseases 4. Any other severe diseases 5. Platelets <100/nl, Quick <50 6. Significant findings during clinical examination 7. Participation in a clinical trial within 30 days before inclusion 8. Abuse of hard drugs, benzodiacepines, analgesics, alcohol 9. Therapy with anticoagulants
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement of VAS pain of at least 20 mm on a 0-100 scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Impovement of a numeric pain scale, sleep quality, global daily activity, knee mobility with Lysholm and Gilquist Score, Western Ontario McMaster Universities Osteoarthritis (WOMAC) index, relief of pain on a numeric scale from 0-3. | — |
Countries
Germany
Outcome results
None listed