Study of bone cell changes in steroid-related femoral head necrosis using discarded tissue from routine hip replacement surgery

Case-control study of osteoblastic mitochondrial quality control disorder in glucocorticoid-induced osteonecrosis of the femoral head

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN72490358

Enrollment

Registered

2026-03-03

Start date

2026-03-01

Completion date

Unknown

Last updated

2026-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glucocorticoid-induced osteonecrosis of femoral head Musculoskeletal Diseases

Interventions

This is a non-interventional case-control study with a 1:1 matching design. The case group consists of patients diagnosed with glucocorticoid-induced osteonecrosis of femoral head (GONFH) who require

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Patients diagnosed with glucocorticoid-induced osteonecrosis of femoral head (GONFH) or femoral neck fracture, who need total hip arthroplasty 2. Aged 18-70 years old 3. Femoral neck fracture patients are matched 1:1 with GONFH patients by age (±5 years) and same gender 4. The interval between injury and total hip arthroplasty is less than 3 weeks for femoral neck fracture patients 5. GONFH patients meet Ficat stage II-IV 6. Voluntarily participate and sign the informed consent form

Exclusion criteria

Exclusion criteria: 1. Complicated with other metabolic bone diseases, such as severe osteoporosis, hyperparathyroidism 2. Complicated with other diseases that may cause abnormal bone metabolism, such as severe diabetes, gout 3. Complicated with malignant tumors

Countries

China

Contacts

Public ContactXiaoxia Yan

641594851@qq.com+86 (0)18736095609

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 20, 2026