Yellow fever Infections and Infestations Yellow fever
Conditions
Interventions
Two groups (allocation ratio 1:1) will be compared:
1. 17DD yellow fever vaccine, which is currently used for routine immunisation of residents and travellers to endemic areas in Brazil
2. A vaccine
Sponsors
Bio-Manguinhos (Brazil)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Children aged between 9 and 23 months, brought by their guardians to public health care units in regions where vaccination against yellow fever is recommended by the Brazilian National Program of Immunisation
Exclusion criteria
Exclusion criteria: 1. Severe malnutrition 2. Transitory or permanent immunodeficiency 3. Treatment with immunoglobulin or blood products 4. Administration of experimental drugs or vaccines in the previous 60 days or next 60 days of yellow fever vaccination 5. Hypersensitivity to chicken egg products or gelatin 6. Chronic or acute conditions constituting temporary contraindications to routine 7. Immunisation 8. Fever above 37.5°C 9. Mothers unwilling or unable to return 30 days after vaccination for blood collection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Seroconversion from non-responder (before vaccination) to patients exhibiting response or a four-fold increase in yellow fever antibody titers after vaccination. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Adverse events within 30 days of immunisation 2. Seroconversion for measles, rubella and mumps | — |
Countries
Brazil
Outcome results
None listed