Medical Research Council trial of treatment of mild hypertension

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN72268178

Enrollment

18000

Registered

2005-09-08

Start date

1973-01-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension Circulatory System Hypertension

Interventions

Bendrofluazide or propranolol compared with placebo.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Men and women age 35-64 at recruitment in 176 general practices in the Medical Research Council's General Practice Research Framework. Diastolic blood pressure of 90-109 mmHg with a systolic pressure below 200 mmHg.

Exclusion criteria

Exclusion criteria: Secondary hypertension; already on antihypertensive treatment; accepted indication for antihypertensive treatment; myocardial infarction or stroke within previous three months; presence of angina, intermittent claudication, diabetes, gout, bronchial asthma, serious intercurrent disease, pregnancy.

Design outcomes

Primary

Measure	Time frame
Stroke, deaths due to hypertension and of coronary events.	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026