Can increased urine flow encouraged by the drug furosemide and increased water intake prevent kidney injury caused by the contrast media used in angiography procedures in patients with reduced kidney function?

Contrast-Induced Nephropathy: Evaluation of MAtched hydration and furosemide in risky patients undergoing chronic total occlusion-percutaneous coronary intervention (CINEMA)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN72194653

Enrollment

998

Registered

2019-07-23

Start date

2018-01-01

Completion date

Unknown

Last updated

2020-11-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prevention of contrast-induced nephropathy in patients with impaired renal function undergoing percutaneous coronary interventions for chronic total occlusion of the coronary arteries Urological and Genital Diseases

Interventions

After patients have agreed to take part in the study, those with baseline eGFR 300 ml/h is obtained. The hydration will be continued throughout the duration of the procedure and will last 4 h followin

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Estimated GFR of <60 mL/min/1.73 m2 2. Receiving contrast media for invasive coronary angiography or intervention

Exclusion criteria

Exclusion criteria: 1. Aged under 18 years 2. Allergy to furosemide 3. Severe LV dysfunction 4. Receiving dialysis

Design outcomes

Primary

Measure	Time frame
Contrast-induced acute kidney injury defined as an increase in serum creatinine concentration of 25% or 0.5 mg/dl from the baseline to 48 h after contrast medium exposure	—

Countries

Iraq

Contacts

Public ContactAram Mirza

aram@arammirza.com009647701570490

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026