Uremic myopathy in end-stage renal disease patients undergoing dialysis Urological and Genital Diseases Uremic myopathy
Conditions
Interventions
Exercise and intake of protein or non-protein energy:
Strength training for lower limbs three times per week in 16 weeks (48 sessions). The patients were randomised to exercise and a protein intake af
Sponsors
University of Copenhagen (Denmark)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age above 18 years 2. Dialysis more than three months 3. Able to do strength training 4. Able to talk and read Danish
Exclusion criteria
Exclusion criteria: 1. Blindness 2. Lower limb amputation 3. Diabetic retinopathy 4. Anticoagulation treatment by Fondaparinux (Arixtra®) 5. Mental reduction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Muscle strength (equipment: Good Strength) 2. Muscle power (equipment: Power Rig) 3. Physical function (Chair stand test from The Senior Fitness Test) 4. Selfrated health (Short Form 36 questionaire) 5. Muscle size and type (muscle biopsy from the vastus lateralis muscle) 6. Electromyography (EMG) (surface from the vastus lateralis muscle) 7. Anabolic hormones (blood tests) 8. Insulin resistance (the oral glucose tolerence test) All tests are done three times: A pretest 16 weeks before the baseline test with no intervention in between and a final retest after the 16 weeks of intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Physical activity 2. Food intake 3. Body weight 4. Kidney function All tests are done three times: A pretest 16 weeks before the baseline test with no intervention in between and a final retest after the 16 weeks of intervention | — |
Countries
Denmark
Outcome results
None listed