Chronic knee pain associated with imaging findings of mild to moderate degenerative changes in the knee joint Musculoskeletal Diseases
Conditions
Interventions
Randomization was performed using a computer-generated program. The enrolled patients were randomly distributed into three groups:
Group I included 20 patients who received two PRP in
Wako Pure Chemical Industries, Ltd.). Then, it was placed in a centrifuge first spin at a force of 3,000 RPM for 3 minutes to separate erythrocytes from the plasma. After that, the obtained plasma was
Sponsors
Dubai Health Authority
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. History of chronic (at least 4 months) pain or swelling of the knee 2. Imaging findings (radiography) of mild to moderate degenerative changes in the knee joint on Kellgren–Lawrence scale from I–III
Exclusion criteria
Exclusion criteria: 1. Age >80 years 2. Rheumatic pathologies (rheumatoid, psoriatic and reactive arthritis, and seronegative spondyloarthritis) 3. Hematological diseases (coagulopathies) 4. Severe systemic diseases (renal, hepatic, cardiac, infections, endocrinopathies, malignancies) 5. Patients on therapy with anticoagulants–anti-aggregants 6. Use of NSAIDs within 5 days before blood procedure 7. Grade IV gonarthrosis 8. History of knee operarion, or recent knee trauma 9. Previous intra-articular injection with steroids, HA and/or PRP 10. Hb values<11 g/dl, and/or platelet values<150.000/mm3
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain severity measured using Visual Analogue Scale (VAS) of shoulder pain initially, then after 2 and 6 months of therapy. Patients point to their amount of pain on a scale of zero (no pain) to 100 (agonizing severe pain), according to their subjective feelings on a 100-millimeter scale drawn on paper. In this scale, a higher score indicates much pain. | — |
Secondary
| Measure | Time frame |
|---|---|
| Measured initially, then after 2 and 6 months of therapy: 1. Physical knee examination: limitation in knee range of motion (ROM) and assessment of the presence of effusion 2. Western Ontario and McMaster Universities Arthritis Index (WOMAC): WOMAC comprises 24 multiple-choice items. Each item is scored using a 5-point scale (with 1 point indicating the best function and 5 points, the worst): aggregate scores for joint-specific pain (5 items), physical function (17 items), and stiffness (2 items) are calculated. Use of an overall score is not recommended. 3. Health-related quality of life measured by RAND 36-Item Short-Form Health Survey (SF-36): 36-Item SF-36 is a self-administered 36-item questionnaire comprising 8 health dimensions: physical function (PF), bodily pain (BP), role limitations related to physical health (PR), general health(GH), mental health (MH), role limitations related to emotional health (ER), vitality (VT) and social functioning (SF). Scoring for the eight dimensions ranges from 0 to 100 points, with higher scores indicating better health. 4. NSAIDs consumption: number of days over the past week the patient had consumed NSAID tablets 5. Patient satisfaction registered by means of five-point Likert Scale (not at all satisfied; slightly satisfied; somewhat satisfied; very satisfied; extremely satisfied) | — |
Countries
United Arab Emirates
Outcome results
None listed