REACT Trial: Supporting relatives of people with psychosis or bipolar disorder

Conditions

Topic: Mental Health, Primary Care

Fiona Lobban, Nadia Akers, D. E. Appelbe, Rossella Iraci Capuccinello, L. J. Chapman et al. (22 authors)

Health Technology Assessment2020-06-0123 citations

Clinical effectiveness of a web-based peer-supported self-management intervention for relatives of people with psychosis or bipolar (REACT): online, observer-blind, randomised controlled superiority trial.

Lobban F, Akers N, Appelbe D, Chapman L, Collinge L, Dodd S, Flowers S, Hollingsworth B, Johnson S, Jones SH, Mateus C, Mezes B, Murray E, Panagaki K, Rainford N, Robinson H, Rosala-Hallas A, Sellwood W, Walker A, Williamson P.

2020-04-1427 citations

10.1186/s12888-020-02545-9

Protocol for an online randomised controlled trial to evaluate the clinical and cost-effectiveness of a peer-supported self-management intervention for relatives of people with psychosis or bipolar disorder: Relatives Education And Coping Toolkit (REACT)

Fiona Lobban, Heather Robinson, Duncan Appelbe, Johanna Barraclough, Emma Bedson et al. (18 authors)

BMJ Open2017-07-0120 citations

10.1136/bmjopen-2017-016965

Interventions

Current interventions as of 23/10/2017: Participants are randomly allocated to one of two groups. Participants in both groups continue to receive treatment as usual (TAU) throughout th

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged 16 or over. 2. Are the relative or close friend of someone with a psychosis or bipolar disorder (removed 23/10/2017: friends are required to have a period of at least 6 months within the last 2 years during which there was regular contact) 3. Distressed (according to GHQ score) 4. Currently seeking help 5. Regular access to a computer which is connected to the internet 6. A good working knowledge of written and spoken English

Exclusion criteria

Exclusion criteria: (Removed 23/10/2017: Currently taking part in another research study evaluating an intervention for relatives of people with mental health problems) 1. Living outside the UK 2. Living in any of the 6 areas involved in the IMPART study

Design outcomes

Primary

Measure	Time frame
Relatives' distress is measured using the General Health Questionnaire (GHQ-28) at 24 weeks	—

Secondary

Measure	Time frame
Current secondary outcome measures as of 23/10/2017: 1. Relatives' distress is measured using the General Health Questionnaire (GHQ-28) at 12 weeks 2. Relatives' well-being is measured using the Carers' Well-Being and Support Measure (CWS) at 12 and 24 weeks 3. Costs of delivering the intervention versus NHS and productivity cost savings in use of health services and paid work (adapted version of the CSRI) at baseline, 12 and 24 weeks 4. Cost effectiveness – cost of significant unit change (defined as 3 point reduction) in primary outcome (GHQ-28) at baseline, 12 and 24 weeks 5. Cost utility – marginal cost of any changes in marginal change in quality adjusted life years (QALYs) (making use of the EQ-5D-5L, as recommended by NICE) at baseline, 12 and 24 weeks 6. Mechanism of change for the REACT intervention is measured using the Brief Illness Perception Questionnaire (BIPQ) and Brief COPE at baseline, 12 and 24 weeks Previous secondary outcome measures: 1. Relatives' well-being is measured using the Carers' Well-Being and Support Measure (CWS) at 24 weeks 2. Costs of delivering the intervention versus NHS and productivity cost savings in use of health services and paid work (adapted version of the CSRI) at baseline, 12 and 24 weeks 3. Cost effectiveness – cost of significant unit change (defined as 3 point reduction) in primary outcome (GHQ-28) at baseline, 12 and 24 weeks 4. Cost utility – marginal cost of any changes in marginal change in quality adjusted life years (QALYs) (making use of the EQ-5D-5L, as recommended by NICE) at baseline, 12 and 24 weeks 5. Mechanism of change for the REACT intervention is measured using the Brief Illness Perception Questionnaire (BIPQ) and Brief COPE at baseline, 12 and 24 weeks	—

Measure

Time frame

Current secondary outcome measures as of 23/10/2017: 1. Relatives' distress is measured using the General Health Questionnaire (GHQ-28) at 12 weeks 2. Relatives' well-being is measured using the Carers' Well-Being and Support Measure (CWS) at 12 and 24 weeks 3. Costs of delivering the intervention versus NHS and productivity cost savings in use of health services and paid work (adapted version of the CSRI) at baseline, 12 and 24 weeks 4. Cost effectiveness – cost of significant unit change (defined as 3 point reduction) in primary outcome (GHQ-28) at baseline, 12 and 24 weeks 5. Cost utility – marginal cost of any changes in marginal change in quality adjusted life years (QALYs) (making use of the EQ-5D-5L, as recommended by NICE) at baseline, 12 and 24 weeks 6. Mechanism of change for the REACT intervention is measured using the Brief Illness Perception Questionnaire (BIPQ) and Brief COPE at baseline, 12 and 24 weeks Previous secondary outcome measures: 1. Relatives' well-being is measured using the Carers' Well-Being and Support Measure (CWS) at 24 weeks 2. Costs of delivering the intervention versus NHS and productivity cost savings in use of health services and paid work (adapted version of the CSRI) at baseline, 12 and 24 weeks 3. Cost effectiveness – cost of significant unit change (defined as 3 point reduction) in primary outcome (GHQ-28) at baseline, 12 and 24 weeks 4. Cost utility – marginal cost of any changes in marginal change in quality adjusted life years (QALYs) (making use of the EQ-5D-5L, as recommended by NICE) at baseline, 12 and 24 weeks 5. Mechanism of change for the REACT intervention is measured using the Brief Illness Perception Questionnaire (BIPQ) and Brief COPE at baseline, 12 and 24 weeks

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Countries

England, United Kingdom

Contacts

Public ContactHeather Robinson

Outcome results

None listed